Zack Greinke
| Date | Team | Opponent | Result | IP | H | R | ER | BB | SO | PA | 2B | 3B | HR | GO | FO | MISC |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2021-04-01 | HOU | @ OAK | W, 8-1 | 6.0 | 3 | 0 | 0 | 0 | 4 | 19 | 1 | 0 | 0 | 5 | 7 | SP, W |
| 2021-04-06 | HOU | @ LAA | W, 4-2 | 7.0 | 5 | 2 | 2 | 1 | 4 | 26 | 1 | 0 | 1 | 5 | 11 | SP |
| 2021-04-12 | HOU | vs. DET | L, 6-2 | 4.2 | 10 | 6 | 6 | 3 | 2 | 27 | 1 | 0 | 3 | 6 | 6 | SP, L |
| 2021-04-17 | HOU | @ SEA | W, 1-0 | 8.0 | 4 | 0 | 0 | 0 | 6 | 27 | 0 | 0 | 0 | 8 | 9 | SP, W |
| 2021-04-23 | HOU | vs. LAA | W, 5-4 | 7.0 | 10 | 2 | 2 | 0 | 6 | 29 | 3 | 0 | 0 | 5 | 6 | SP |
| 2021-04-28 | HOU | vs. SEA | W, 7-5 | 4.0 | 4 | 4 | 4 | 2 | 5 | 19 | 3 | 0 | 1 | 4 | 3 | SP |
| 2021-05-04 | HOU | @ NYY | L, 7-3 | 4.0 | 3 | 3 | 3 | 4 | 4 | 18 | 0 | 0 | 1 | 6 | 1 | SP |
| 2021-05-09 | HOU | vs. TOR | W, 7-4 | 4.0 | 9 | 4 | 4 | 0 | 4 | 21 | 2 | 0 | 1 | 5 | 3 | SP |
| 2021-05-14 | HOU | vs. TEX | W, 10-4 | 7.0 | 7 | 3 | 3 | 1 | 5 | 28 | 3 | 0 | 0 | 10 | 5 | SP, W |
| 2021-05-19 | HOU | @ OAK | W, 8-1 | 8.0 | 4 | 1 | 1 | 0 | 8 | 27 | 1 | 0 | 0 | 7 | 8 | SP, W |
| 2021-05-25 | HOU | vs. LAD | L, 9-2 | 6.0 | 3 | 4 | 4 | 3 | 5 | 24 | 0 | 0 | 1 | 5 | 8 | SP, L |
| 2021-05-30 | HOU | vs. SDP | W, 7-4 | 8.0 | 6 | 1 | 1 | 1 | 4 | 29 | 0 | 0 | 1 | 9 | 9 | SP, W |
| 2021-06-04 | HOU | @ TOR | W, 13-1 | 9.0 | 6 | 1 | 1 | 1 | 3 | 32 | 0 | 0 | 1 | 8 | 14 | SP, W, CG |
| 2021-06-10 | HOU | @ BOS | L, 12-8 | 3.0 | 7 | 4 | 4 | 1 | 2 | 17 | 1 | 0 | 1 | 4 | 3 | SP |
| 2021-06-16 | HOU | vs. TEX | W, 8-4 | 5.2 | 4 | 3 | 3 | 2 | 4 | 22 | 0 | 0 | 1 | 7 | 5 | SP, W |
| 2021-06-22 | HOU | @ BAL | W, 3-1 | 7.1 | 5 | 1 | 1 | 1 | 4 | 26 | 1 | 0 | 0 | 4 | 11 | SP, W |
| 2021-06-28 | HOU | vs. BAL | L, 9-7 | 5.0 | 8 | 3 | 3 | 1 | 4 | 23 | 0 | 0 | 1 | 5 | 5 | SP |
| 2021-07-04 | HOU | @ CLE | W, 4-3 | 7.2 | 5 | 3 | 3 | 1 | 8 | 29 | 1 | 0 | 2 | 8 | 6 | SP |
| 2021-07-10 | HOU | vs. NYY | L, 1-0 | 4.0 | 3 | 1 | 1 | 1 | 3 | 16 | 1 | 0 | 1 | 3 | 6 | SP, L |
| 2021-07-19 | HOU | vs. CLE | W, 4-3 | 5.1 | 5 | 2 | 2 | 1 | 4 | 21 | 0 | 0 | 1 | 7 | 4 | SP, W |
| 2021-07-25 | HOU | vs. TEX | W, 3-1 | 6.0 | 5 | 1 | 1 | 2 | 4 | 26 | 0 | 0 | 1 | 10 | 4 | SP, W |
| 2021-07-31 | HOU | @ SFG | L, 8-6 | 4.0 | 8 | 6 | 4 | 2 | 4 | 22 | 1 | 0 | 4 | 6 | 1 | SP |
| 2021-08-06 | HOU | vs. MIN | L, 5-4 | 6.0 | 6 | 3 | 3 | 1 | 3 | 25 | 1 | 0 | 1 | 9 | 6 | SP |
| 2021-08-13 | HOU | @ LAA | W, 4-1 | 7.0 | 2 | 0 | 0 | 0 | 7 | 23 | 1 | 0 | 0 | 4 | 10 | SP, W |
| 2021-08-18 | HOU | @ KCR | L, 3-2 | 6.0 | 5 | 1 | 1 | 0 | 0 | 22 | 0 | 0 | 0 | 7 | 10 | SP |
| 2021-08-23 | HOU | vs. KCR | L, 7-1 | 6.0 | 6 | 2 | 2 | 1 | 2 | 25 | 2 | 0 | 1 | 12 | 4 | SP, L |
| 2021-08-29 | HOU | @ TEX | L, 13-2 | 4.0 | 9 | 6 | 6 | 2 | 1 | 23 | 4 | 0 | 1 | 5 | 5 | SP, L |
| 2021-09-14 | HOU | @ TEX | L, 8-1 | 5.0 | 5 | 8 | 7 | 3 | 4 | 24 | 1 | 0 | 3 | 7 | 4 | SP, L |
| 2021-09-19 | HOU | vs. ARI | W, 7-6 | 4.0 | 5 | 5 | 5 | 1 | 3 | 18 | 0 | 0 | 1 | 6 | 3 | SP |
| 2021-10-03 | HOU | vs. OAK | W, 7-6 | 2.1 | 2 | 2 | 2 | 0 | 3 | 9 | 0 | 0 | 1 | 4 | 0 | RP |
| 2021-10-10 | HOU | @ CHW | L, 12-6 | 1.0 | 2 | 0 | 0 | 0 | 1 | 6 | 0 | 0 | 0 | 2 | 0 | RP |
| 2021-10-19 | HOU | @ BOS | W, 9-2 | 1.1 | 1 | 2 | 2 | 3 | 0 | 9 | 0 | 0 | 1 | 3 | 1 | SP |
| 2021-10-30 | HOU | @ ATL | L, 3-2 | 4.0 | 4 | 0 | 0 | 0 | 3 | 14 | 0 | 0 | 0 | 4 | 3 | SP |
| Total Games: 33 | ||||||||||||||||