Edward Henry Wilkinson (June 20, 1890 – April 9, 1918) was a Major League Baseball player. He was born in Jacksonville, Oregon and died in Tucson, Arizona. Wilkinson batted and threw right-handed.
Wilkinson played for the New York Highlanders in the 1911 season. In ten games, he had three hits in 13 at-bats, with one RBI, and a .231 batting average. Shortly thereafter, he contracted pulmonary tuberculosis, a condition that ended his career and contributed to his early death at the age of 27.